- Short tandem repeats - short sequences of DNA - repeated many times tandemly in the genome - STR analysis - is a method of DNA profiling - compares the lengths of STR sequences at specific sites in the genome - STR analysis - compare the lengths of DNA fragments - uses gel electrophoresis a method for sorting macromolecules—usually proteins or nucleic acids—primarily by their electrical charge and size - DNA fragments are visualized as bands on the gel - The differences in the locations of the bands reflect the different lengths of the DNA fragments - Genome mapping - the entire genome is chopped into fragments using restriction enzymes - all the fragments are cloned and sequenced - computers are running specialized mapping software reassemble the millions of overlapping short sequences into a single continuous sequence for every chromosome—an entire genome - Human gene therapy - is a recombinant DNA procedure - seeks to treat disease by altering the genes of the afflicted person - often replaces or supplements the mutant version of a gene with a properly functioning one